- Adults with a body mass index (BMI) of 30 or greater (classified as obese).
- Adults with a BMI of 27 or greater (overweight) who also have at least one weight-related medical condition, such as type 2 diabetes, high blood pressure, or high cholesterol.
How Does Zepbound Work in the Body?
- GLP-1 Receptor (Glucagon-Like Peptide-1)
- GIP Receptor (Glucose-Dependent Insulinotropic Polypeptide)
- Slows stomach emptying: Food stays in your stomach longer, making you feel full faster and longer.
- Signals the brain: It targets the areas of the brain responsible for appetite regulation, drastically reducing feelings of hunger and persistent food cravings.
- Regulates blood sugar: By stimulating insulin secretion and decreasing the amount of sugar made by the liver, it helps stabilize blood sugar levels.
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Zepbound vs. Other Weight Loss Medications
- Mechanism: Dual agonist (targets GLP-1 and GIP receptors).
- Administration: Once-weekly injection.
- Clinical Results: Average weight loss of up to 20.9% in clinical trials.
- Mechanism: Single agonist (targets only GLP-1 receptors).
- Administration: Once-weekly injection.
- Clinical Results: Average weight loss of about 15% in clinical trials.
Potential Side Effects of Zepbound
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain or upset stomach
- Injection site reactions
How to Use Zepbound Safely
- Starting Dose: 2.5 mg once a week for 4 weeks.
- Dose Escalation: Your doctor will typically increase the dose to 5 mg once a week. The dose may be increased further in 2.5 mg increments, up to a maximum maintenance dose of 15 mg per week, depending on your tolerance and weight loss progress.



